Welcome to the 10x Blog

From tips and tricks to 10x news, our blog is here to help you learn about all things 10x. Let us know what topics you would like to see in the Community Suggestions forum.

New study uses Linked-Reads to help resolve complex structural variation

In a recent publication from the Broad Institute of MIT and Harvard, researchers identified >11,000 distinct structural variations among participants with autism spectrum disorder. These results provide new insights into the extent and diversity of structural variation present in the morbid human genome.

Meet 10x's Sofia Panagiotopoulou

To celebrate Women's History Month we talked to four 10x’ers about how they got into science, what they do at 10x, and how we can all promote women in science.  Today, we are finding out more about Sofia Panagiotopoulou, a senior scientist on our Computational Biology team.

Decoupling time and location from single-cell RNA sequencing analysis

A key challenge across all single-cell RNA-sequencing (scRNA-seq) techniques is the preservation of each cell’s transcriptional profile throughout the entire sample handling process.  Two recent publications have developed similar cryopreservation techniques that can be readily implemented into scRNA-seq workflows.

Meet 10x's Jill Herschleb

To celebrate Women's History Month we talked to four 10x’ers about how they got into science, what they do at 10x, and how we can all promote women in science.  First, up we've got Jill L. Herschleb, our Sample Prep group leader.

InPSYght sequencing project incorporates Linked-Read data

The InPSYght schizophrenia and bipolar disorder sequencing project seeks to produce Whole Genome Sequencing (WGS) data to identify variants associated with disease, build a reference panel of structural events and haplotypes to impute into large genotype data sets, and create and share data and methods with the community.

SIMLR - A novel scRNA-seq analysis method

We recently had a chance to speak with Bo Wang, lead author on the new Nature Methods paper, "Visualization and analysis of single-cell RNA-seq data by kernel-based similarity learning", about the current challenges and future potential of single cell analysis.

Join us on March 21st at the South San Francisco Convention Center

Hear your colleagues, industry leaders and 10x scientists discuss single cell genomics, de novo assembly and how to make the most of the human genome with Linked-Reads.

A novel scRNA-seq analysis method uses machine learning

The novel approach called SIMLR (single-cell interpretation via multi-kernel learning), learns appropriate cell-to-cell similarity metrics for dimension reduction and clustering of single cell RNA-seq data.

10x Genomics at AGBT 2017

    The annual Advances in Genome Biology and Technology (AGBT) General Meeting took place from February 14th – 16th in sunny Hollywood, FL and was filled with exciting scientific presentations and discussions. 

Our 1.3 million single cell dataset is ready to download

Why share our 1.3 million cell dataset? We believe the public sharing of single cell data will fuel biological discovery and enable big-data software tool development.

Fast and scalable single cell analysis with the new Loupe™ Cell Browser

The new Loupe™ Cell Browser makes it easy to perform single cell analysis to identify cell populations, isolate significant genes and measure expression levels - even for million cell datasets

Everything you wanted to know about Linked-Reads

Check out our growing list of resources and learn how to make the most of the human genome with Linked-Reads.

PAG XXV Round-up

Here are the 10x highlights from San Diego, and a peek ahead at some of our upcoming events.

Open Discussion, Open Discovery

We built the 10x Community around the belief that scientific development thrives with communication and collaboration among colleagues. Now, we're excited to introduce our newest Community additions, the Data Sharing Forum and Developers Network. 

Most comprehensive single cell analysis of AML gene expression to date

In a recent Nature Communications publication, researchers at the Fred Hutchinson Cancer Research Center and 10x use single cell analysis to profile Leukemia patients who had undergone bone marrow transplant.

10x Workshop at AGBT 2017

Book your flights early and join us on Monday Feb. 13, at the Diplomat Hotel in Hollywood, FL to hear how your colleagues are using 10x Technology to advance their research.

You're invited to a 10x UGM near you!

Join us in a city near you to hear your colleagues and 10x scientists discuss single cell genomics, de novo assembly and making the most of the human genome with Linked-Reads.

Linked-Reads used in new NIPT approach

In a recent publication, researchers at the University of Hong Kong used 10x Linked-Reads in the prenatal identification of single gene disorders.

Researcher Spotlight: Resolving short reads and distinguishing variants in PMS2

Recently, we got to talk to Dr. Charlly Kao of CHOP about how Linked-Reads play a part in his current research, possible future applications, and why 10x technology is so exciting.

Perturb-seq: High throughput functional genomics at single cell resolution

Two new publications in Cell describe a novel approach to high-throughput functional genomics enabled by the combination of single cell RNA-seq with CRISPR perturbations call Perturb-seq.

Structural Variant Analysis with Linked-Reads

The Chromium™ Genome and Exome Solutions use Linked-Reads to provide long range information from short read sequencers, giving you the power to detect complex SVs.

Cell Ranger™ Software 1.2 is here!

The latest release of Cell Ranger™ Software 1.2 for single cell data analysis includes updates for scalability, usability and analysis improvements.

More Complete HLA Analysis

Linked-Read data generated by the Chromium™ Genome Solution can be used for MHC analysis with Long Ranger™ Software.

New DNA Application Tech Notes now available

Our six new Technical Notes cover topics including library QC, Linked-Read technology and HMW DNA sample preparation.

New Chromium™ Genome Kits increase workflow flexibility

We are excited to annouce the new Chromium Genome Kit v2, now available in an automation-friendly 96-reaction kit.  

ASHG 2016 Round-up

In case you missed it, here's a recap of all things 10x at this year's ASHG annual meeting.

De novo Assembly of the Sitka Spruce Chloroplast Genome using Linked-Reads

In a recently published paper, entitled “Assembly of the Complete Sitka Spruce Chloroplast Genome Using 10X Genomics’ GemCode Sequencing Data” researchers used GemCode’s novel Linked-Read data type for de novo assembly of a complete chloroplast genome.

10x Twitter Week in Review: Sept. 26

Check out what's been happening in the 10x Twitterverse - #ASHG16 events, Nature Webcast, a new 10x publication and 10x technology gets "buzzed".  

Single cell RNA-Seq data analysis using Cell Ranger and Seurat

With the power to interrogate complex systems, comes the need to analyze complex single cell datasets.  10x Genomics and the single cell research community are working hard to develop computational solutions that are approachable to both seasoned bioinformaticians and beginners alike.

10x Twitter Week in Review: Sept. 19

See what's been trending in the 10x Twitter world - new software releases, Genome Informatics 2016 and 10x technology heads down under.