Welcome to the 10x Blog

From tips and tricks to 10x news, our blog is here to help you learn about all things 10x. Let us know what topics you would like to see in the Community Suggestions forum.

In a recent article in GEN, Brian Fritz, Ph.D. describes how the Chromium™ Single Cell V(D)J Solution reveals true T-cell diversity by combining microfluidics and 5' molecular barcoding to assemble full-length V(D)J sequences on a cell-by-cell basis.
A collaborative research study with Stanford University School of Medicine researchers was recently published in Nature. The article, “Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal,” describes how the 10x Genomics’ Single Cell 3’ Solution for single-cell RNA-seq (scRNA-seq) was utilized to help unravel the priming and self-renewal mechanisms of intestinal stem cells (ISCs).     
Using single-cell sequencing and a battery of molecular tools, the authors achieved unprecedented insight into epithelial cell lineage relationships and the dynamics of differentiation in murine lacrimal gland development.
The International Society for Stem Cell Research (ISSCR) annual meeting brings together stem cell researchers from around the world to share their work, discuss tools and techniques, and advance stem cell science and regenerative medicine.  Join us for our Innovation Showcase on Friday June 16 featuring 10x's Tarjei Mikkelsen and featured guest speaker, Julie Sneddon, Assitant Professor, UCSF School of Medicine.
There are many examples of how microbes influence the behavior of animals; however, studying the molecular basis for microbial behavior manipulation has suffered from a lack of tools. At our Bay Area User Group Meeting, Carolyn Elya spoke about establishing a D. melanogaster – E. muscae system and setting out to sequence and assemble the mind-controlling fungal pathogen.
Using 10x Linked-Read technology combined with standard, short-read sequencing, Dr. Noah Spies and his team at Stanford University were able to develop a statistical method for complex structural variant detection—Genome-wide Reconstruction of Complex Structural Variants (GROC-SVs).
The Supernova™ Assembler enables true diploid assembly from Linked-Reads and the latest release makes everyday de novo assembly more accessible than ever.
Profile full-length paired V(D)J transcripts from hundreds to millions of lymphocytes with the new Chromium™ Single Cell V(D)J Software Suite – part of the Chromium™ Single Cell V(D)J Solution.
Seattle Children’s announces the first clinical trial applying next-generation T-cell receptor (TCR) sequencing and single-cell gene expression analysis to better understand the role of the immune system in inflammatory bowel disease and graft-versus host disease in pediatric patients.
We'll be at ESHG 2017 in Copenhagen! Join us for our Corporate Satellite on Monday, May 29th to hear more about the Chromium System, 10x Software Solutions and more.
There’s a growing number of data analysis tools being developed for single cell and Linked-Read applications, including gene expression, genome assembly, structural variant detection and more.  Check out the list we’ve compiled so far.
Genomic analysis is an important tool for conservation biology, enabling researchers to help better understand and preserve endangered species. In a new Biorxiv preprint, researchers at Johns Hopkins describe a cost-effective and low DNA input method of de novo assembly for the endangered Hawaiian monk seal genome using 10x Linked-Reads and Supernova™ software.
Although thousands of human genomes have been sequenced in the last decade, de novo assembly of individual genomes is not common due to the high cost and experimental burden.  In a recent Genome Research paper, Weisenfeld et al describe a straightforward, low cost method for creating true diploid de novo assemblies using 10x Genomics Linked-Reads and the Supernova™ assembler.
Five scientists from Fred Hutchinson Cancer Research Center were awarded the initial stage of funding in a competition sponsored by the Immunotherapy Integrated Research Center to develop projects that utilize single-cell RNA sequencing and 10x Genomics technology.
The large scale and repetitive nature of conifer genomes make them an important benchmark for assembly technologies. At 31 Gb, the Pinus lambertiana (sugar pine) genome is the largest genome assembled to date. Using the GemCode™ System from 10x Genomics, researchers at UC Davis scaffolded the de novo assembly and produced a new reference assembly for sugar pine with 8-fold improvement in contiguity.
This month The Scientist is featuring a 10x Genomics infographic, “Revolutionizing Gene Expression with Single-Cell RNA-seq”, recognizing the promise of single cell analysis for powering discoveries in immunology, neurology, stem cell biology, oncology, and immuno-oncology.
It’s the last day of #AACR17 and there’s still some great science to be seen.  And, don’t forget to stop by Booth #1644 to see how our single cell analysis and Linked-Read genomic analysis solutions can help advance your cancer research. 
It’s day four at #AACR17 and the inspiring science continues.  Refuel with some coffee and check out these posters that utilized 10x technology for single cell analysis and whole genome sequencing (WGS) with Linked-Reads.
AACR is officially in full swing!  Make sure to check out Poster 1436 "Identification of novel tumor suppressor candidates in familial cholangiocarcinoma using sequencing-based Megabase-scale haplotypes from germline and cancer genomes" today from 8am - 12pm in Section 17, Board 5.
Today’s the day! Don’t miss our workshop “Comprehensive Single Cell Analysis and Cancer Genomics with the Chromium™ System” featuring talks by 10x's Tarjei Mikkelsen and Dr. Hanlee Ji from Stanford University.
AACR 2017 has officially begun, and we want to make sure you stay up-to-date with all the exciting 10x events and announcements going on here in Washington, D.C.  Here's what's going on for Day 1.
To celebrate Women's History Month we talked to four 10x’ers about how they got into science, what they do at 10x, and how we can all promote women in science.  March is almost over, but we've still one more 10x’er for you to meet - Kamila Belhocine, a scientist on our molecular biology team.
We're going to be introducing our new Chromium™ Single Cell V(D)J Solution at the annual meeting of the American Association for Cancer Research (AACR) in Washington, DC and invite you to attend our workshop on Sunday, April 2 to learn more about he first high-throughput solution for profiling paired V(D)J transcripts.
To celebrate Women's History Month we talked to four 10x’ers about how they got into science, what they do at 10x, and how we can all promote women in science.  We're starting this week off with Lauren Wong, a member of our production team!
We are excited to announce the launch of our new Chromium™ Single Cell V(D)J Solution. It is the first high-throughput solution for profiling paired V(D)J transcripts from hundreds to millions of lymphocytes and expands our industry-leading single-cell product portfolio.
In a recent publication from the Broad Institute of MIT and Harvard, researchers identified >11,000 distinct structural variations among participants with autism spectrum disorder. These results provide new insights into the extent and diversity of structural variation present in the morbid human genome.
To celebrate Women's History Month we talked to four 10x’ers about how they got into science, what they do at 10x, and how we can all promote women in science.  Today, we are finding out more about Sofia Panagiotopoulou, a senior scientist on our Computational Biology team.
A key challenge across all single-cell RNA-sequencing (scRNA-seq) techniques is the preservation of each cell’s transcriptional profile throughout the entire sample handling process.  Two recent publications have developed similar cryopreservation techniques that can be readily implemented into scRNA-seq workflows.
To celebrate Women's History Month we talked to four 10x’ers about how they got into science, what they do at 10x, and how we can all promote women in science.  First, up we've got Jill L. Herschleb, our Sample Prep group leader.
The InPSYght schizophrenia and bipolar disorder sequencing project seeks to produce Whole Genome Sequencing (WGS) data to identify variants associated with disease, build a reference panel of structural events and haplotypes to impute into large genotype data sets, and create and share data and methods with the community.
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